Sep Efa (90 Capsules)

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EPA and DHA to support cardiovascular and brain health • Helps reduce serum triglycerides in adults • Supports cognitive health and brain function • Provides 1080 mg EPA and 720 mg DHA per daily dose SEP EFA is a blend of EPA and DHA omega-3 fatty acids that helps support cardiovascular health. Research indicates that EPA and DHA decrease triglycerides by altering gene expression in the liver; they decrease fat production by increasing fatty acid metabolism through PPARα stimulation.1,2 This decrease in triglycerides leads to a reduction in the production of very low-density lipoprotein (VLDL) cholesterol, molecules that transport lipids throughout the body.2,3 In a randomized, double-blind, placebo-controlled trial of 60 hyperlipidemic adults, 3 weeks of daily supplementation with a total of 1.4 g of EPA and DHA significantly reduced serum triglycerides by approximately 20% compared to baseline values.4 DHA is also the most abundant omega-3 fatty acid in the brain: fish oil supplementation has been associated with maintaining neuronal function in the hippocampus, a brain region associated with memory.5 In 36 elderly individuals with mild cognitive impairment, daily supplementation with 1.75 g of DHA and EPA for 12 months resulted in a significant increase in short-term and working memory.6 REFERENCES 1. Davidson, M.H. The American Journal of Cardiology. 2006, 98(4A): 27i-33i. 2. Ikeda, I, Konno, R, Shimizu, T, Ide, T, Takahashi, N, Kawada, T, Nagao, K, Inoue, N, Yanagita, T, Hamada, T, Morinaga, Y, Tomoyori, H, Imaizumi, K, Suzuki, K. Biochimica et Biophysica Acta. 2006, 1760: 800-807. 3. Estronca, LMBB, Filipe, HAL, Salvador, A, Moreno, AJ, Vaz, WLC. Journal of Lipid Research. 2014, 55: 1033-1043. 4. Micallef, M.A., Garg, M.L. The Journal of Nutrition. 2008, 138: 1086-1090. 5. Cederholm, T, Salem, NJ, Palmblad, J.Adv Nutr. 2013, 4(6): 672-676. 6. Lee, LK, Shahar, S, Chin, AV, Yusoff, NAM. Psychopharmacology. 2013, 225(3): 605-612.